8TR5

Cryo-EM structure of the rat P2X7 receptor in the apo closed state

Summary for 8TR5

Entry DOI	10.2210/pdb8tr5/pdb
Related	8TRJ 8V4S
EMDB information	41570 41581 42976
Descriptor	P2X purinoceptor 7, GUANOSINE-5'-DIPHOSPHATE, ZINC ION, ... (7 entities in total)
Functional Keywords	membrane protein, ion channel, ligand-gate ion channel, p2x receptor, allosteric antagonist, high-affinity agonist
Biological source	Rattus More
Total number of polymer chains	3
Total formula weight	212999.66
Authors	Oken, A.C.,Lisi, N.E.,Krishnamurthy, I.,McCarthy, A.E.,Godsey, M.H.,Glasfeld, A.,Mansoor, S.E. (deposition date: 2023-08-09, release date: 2024-08-14, Last modification date: 2024-08-21)
Primary citation	Oken, A.C.,Lisi, N.E.,Krishnamurthy, I.,McCarthy, A.E.,Godsey, M.H.,Glasfeld, A.,Mansoor, S.E. High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15:6662-6662, 2024 Cited by PubMed: 39107314 DOI: 10.1038/s41467-024-50771-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.53 Å)

Structure validation