8TM2
Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys
Summary for 8TM2
| Entry DOI | 10.2210/pdb8tm2/pdb |
| Descriptor | NKG2-D type II integral membrane protein, MHC class I polypeptide-related sequence A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
| Functional Keywords | complex mica variant, linked nkg2d, immune system |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 54476.12 |
| Authors | Rupert, P.B.,Strong, R. (deposition date: 2023-07-27, release date: 2024-04-17, Last modification date: 2024-11-13) |
| Primary citation | Rupert, P.B.,Buerger, M.,Girard, E.J.,Frutoso, M.,Parrilla, D.,Ng, K.,Gooley, T.,Groh, V.,Strong, R.K. Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys. Heliyon, 10:e28583-e28583, 2024 Cited by PubMed Abstract: NKG2D and its ligands are critical regulators of protective immune responses controlling infections and cancer, defining a crucial immune signaling axis. Current therapeutic efforts targeting this axis almost exclusively aim at enhancing NKG2D-mediated effector functions. However, this axis can drive disease processes when dysregulated, in particular, driving stem-like cancer cell reprogramming and tumorigenesis through receptor/ligand self-stimulation on tumor cells. Despite complexities with its structure and biology, we developed multiple novel engineered proteins that functionally serve as axis-blocking NKG2D "decoys" and report biochemical, structural, , and evaluation of their functionality. PubMed: 38586421DOI: 10.1016/j.heliyon.2024.e28583 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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