8TM2
Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | NKG2-D type II integral membrane protein | polymer | 264 | 30432.4 | 1 | UniProt (P26718) Pfam (PF00059) In PDB | Homo sapiens (human) | Killer cell lectin-like receptor subfamily K member 1,NK cell receptor D,NKG2-D-activating NK receptor |
2 | C | MHC class I polypeptide-related sequence A | polymer | 188 | 22218.0 | 1 | UniProt (Q29983) Pfam (PF00129) In PDB | Homo sapiens (human) | |
3 | D, B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
4 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
5 | C | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A: 3 - 135 (UniProt: P26718)
A: 136 - 264 (UniProt: P26718)
C: 1 - 182 (UniProt: Q29983)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
C: 1 - 182 (UniProt: Q29983)
PDB | External Database | Details |
---|---|---|
Ala 68 | Gly 91 | conflict |
Trp 69 | Asn 92 | conflict |
Leu 125 | Lys 148 | conflict |
Gln 152 | Lys 175 | conflict |
Asp 154 | Lys 177 | conflict |
Arg 158 | His 181 | conflict |
Phe 166 | Gln 189 | conflict |
His 183 | - | expression tag |
His 184 | - | expression tag |
His 185 | - | expression tag |
His 186 | - | expression tag |
His 187 | - | expression tag |
His 188 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 52650.4 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 976.9 | |
All* | Total formula weight | 54476.1 |