8THR
Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an occluded conformation
Summary for 8THR
Entry DOI | 10.2210/pdb8thr/pdb |
EMDB information | 41269 |
Descriptor | fluorescent protein mVenus,Synaptic vesicular amine transporter,GFP nano body,Synaptic vesicular amine transporter,Synaptic vesicular amine transporter, (3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one (2 entities in total) |
Functional Keywords | monoamine, neurotransmitter, synaptic vesicles, major facilitator superfamily, slc18, transport protein |
Biological source | Aequorea victoria More |
Total number of polymer chains | 1 |
Total formula weight | 94168.35 |
Authors | Dalton, M.P.,Coleman, J.A. (deposition date: 2023-07-17, release date: 2023-10-25, Last modification date: 2024-05-08) |
Primary citation | Dalton, M.P.,Cheng, M.H.,Bahar, I.,Coleman, J.A. Structural mechanisms for VMAT2 inhibition by tetrabenazine. Elife, 12:-, 2024 Cited by PubMed: 38517752DOI: 10.7554/eLife.91973 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.12 Å) |
Structure validation
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