8TB5
TYK2 JH2 bound to Compound7
Summary for 8TB5
Entry DOI | 10.2210/pdb8tb5/pdb |
Descriptor | Non-receptor tyrosine-protein kinase TYK2, ACETATE ION, N-{(3P)-3-[3-(dimethylsulfamoyl)phenyl]-1H-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamide, ... (4 entities in total) |
Functional Keywords | tyk2, pseudokinase, azaindole, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 73873.59 |
Authors | Argiriadi, M.A.,Van Epps, S.A.,Breinlinger, E.C. (deposition date: 2023-06-28, release date: 2023-10-18, Last modification date: 2023-11-08) |
Primary citation | Breinlinger, E.,Van Epps, S.,Friedman, M.,Argiriadi, M.,Chien, E.,Chhor, G.,Cowart, M.,Dunstan, T.,Graff, C.,Hardee, D.,Herold, J.M.,Little, A.,McCarthy, R.,Parmentier, J.,Perham, M.,Qiu, W.,Schrimpf, M.,Vargo, T.,Webster, M.P.,Wu, F.,Bennett, D.,Edmunds, J. Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712. J.Med.Chem., 66:14335-14356, 2023 Cited by PubMed: 37823891DOI: 10.1021/acs.jmedchem.3c01373 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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