8T5I

Crystal structure of human WDR5 in complex with MR4397

Summary for 8T5I

Entry DOI	10.2210/pdb8t5i/pdb
Descriptor	WD repeat-containing protein 5, N-[(2S)-1-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-oxopentan-2-yl]-3-[(1H-imidazol-1-yl)methyl]benzamide, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	wd-repeat, wdr, wdr5, sgc, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	70133.64
Authors	Kimani, S.,Dong, A.,Li, F.,Loppnau, P.,Ackloo, S.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2023-06-13, release date: 2023-08-09, Last modification date: 2024-05-22)
Primary citation	Kimani, S.,Dong, A.,Li, F.,Loppnau, P.,Ackloo, S.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) Crystal structure of human WDR5 in complex with MR4397 To be published,
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation