8T2H
DYRK1A complex with DYR530
Summary for 8T2H
Entry DOI | 10.2210/pdb8t2h/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, (4P)-4-{(3M)-3-[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl}pyridin-2-amine, TETRAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, alzheimer's disease, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 86183.04 |
Authors | |
Primary citation | Montfort, W.R.,Basantes, L.E. Discovery of DYR684, a Potent, Selective, Metabolically Stable, DYRK1A/B PROTAC utilizing a Novel Cereblon Molecular Glue To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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