8SWE
FGFR2 Kinase Domain Bound to Reversible Inhibitor Cmpd 3
Summary for 8SWE
Entry DOI | 10.2210/pdb8swe/pdb |
Descriptor | Fibroblast growth factor receptor 2, GLYCEROL, GLUTATHIONE, ... (5 entities in total) |
Functional Keywords | inhibitor kinase, oncoprotein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 73717.83 |
Authors | |
Primary citation | Schonherr, H.,Ayaz, P.,Taylor, A.M.,Casaletto, J.B.,Toure, B.B.,Moustakas, D.T.,Hudson, B.M.,Valverde, R.,Zhao, S.,O'Hearn, P.J.,Foster, L.,Sharon, D.A.,Garfinkle, S.,Giordanetto, F.,Lescarbeau, A.,Kurukulasuriya, R.,Gerami-Moayed, N.,Maglic, D.,Bruderek, K.,Naik, G.,Gunaydin, H.,Mader, M.M.,Boezio, A.A.,McLean, T.H.,Chen, R.,Wang, Y.,Shaw, D.E.,Watters, J.,Bergstrom, D.A. Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2. Proc.Natl.Acad.Sci.USA, 121:e2317756121-e2317756121, 2024 Cited by PubMed: 38300868DOI: 10.1073/pnas.2317756121 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
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