8SF8

Structure of bovine PKA bound to (R)-N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl)-2-amino-4-methylpentanamide

Summary for 8SF8

• Entry DOI: 10.2210/pdb8sf8/pdb
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, N-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]-D-leucinamide, ... (4 entities in total)
• Functional Keywords: kinase, type i kinase inhibitor, co-crystal structure, cytosolic protein
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 2
• Total formula weight: 43661.60

Authors

Coker, J.A.,Arya, T.,Goins, C.M.,Maw, J.J.,Macdonald, J.D.,Stauffer, S.R. (deposition date: 2023-04-10, release date: 2024-02-21, Last modification date: 2024-03-06)

• Primary citation: Maw, J.J.,Coker, J.A.,Arya, T.,Goins, C.M.,Sonawane, D.,Han, S.H.,Rees, M.G.,Ronan, M.M.,Roth, J.A.,Wang, N.S.,Heemers, H.V.,Macdonald, J.D.,Stauffer, S.R.; Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase.; J.Med.Chem., 67:2631-2666, 2024; PubMed: 38330278; DOI: 10.1021/acs.jmedchem.3c01807

Experimental method

X-RAY DIFFRACTION (1.7 Å)