8ROX
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 12
This is a non-PDB format compatible entry.
Summary for 8ROX
Entry DOI | 10.2210/pdb8rox/pdb |
EMDB information | 19406 |
Descriptor | DDB1- and CUL4-associated factor 15, DNA damage-binding protein 1, DET1- and DDB1-associated protein 1, ... (4 entities in total) |
Functional Keywords | e3 ligase, complex, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 172441.26 |
Authors | Shilliday, F.,Lucas, S.C.C.,Richter, M.,Michaelides, I.N.,Fusani, L. (deposition date: 2024-01-12, release date: 2024-04-03, Last modification date: 2024-05-22) |
Primary citation | Lucas, S.C.C.,Ahmed, A.,Ashraf, S.N.,Argyrou, A.,Bauer, M.R.,De Donatis, G.M.,Demanze, S.,Eisele, F.,Fusani, L.,Hock, A.,Kadamur, G.,Li, S.,Macmillan-Jones, A.,Michaelides, I.N.,Phillips, C.,Rehnstrom, M.,Richter, M.,Rodrigo-Brenni, M.C.,Shilliday, F.,Wang, P.,Storer, R.I. Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders. J.Med.Chem., 67:5538-5566, 2024 Cited by PubMed: 38513086DOI: 10.1021/acs.jmedchem.3c02136 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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