8ROX

Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 12

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DDB1- and CUL4-associated factor 15	polymer	603	66822.6	1	UniProt (Q66K64) Pfam (PF14939) In PDB	Homo sapiens (human)
2	B	DNA damage-binding protein 1	polymer	836	93347.1	1	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
3	D	DET1- and DDB1-associated protein 1	polymer	102	11855.3	1	UniProt (Q9BW61) Pfam (PF10172) In PDB	Homo sapiens (human)	Placenta cross-immune reaction antigen 1,PCIA-1
4	A	5-[[3,4-bis(chloranyl)-1~{H}-indol-7-yl]sulfamoyl]-~{N},~{N},3-trimethyl-furan-2-carboxamide;ethane	non-polymer		416.3	1	Chemie (A1H17)

Sequence modifications

A: 1 - 600 (UniProt: Q66K64)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

B: 1 - 699 (UniProt: Q16531)
B: 706 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Gly 700	-	linker
Asn 701	-	linker
Gly 702	-	linker
Asn 703	-	linker
Ser 704	-	linker
Gly 705	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	172025.0
Non-Polymers*	Number of molecules	1
	Total formula weight	416.3
All*	Total formula weight	172441.3

*Water molecules are not included.