8ROX
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 12
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000209 | biological_process | protein polyubiquitination |
| A | 0002376 | biological_process | immune system process |
| A | 0005515 | molecular_function | protein binding |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0032814 | biological_process | regulation of natural killer cell activation |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
| D | 0000209 | biological_process | protein polyubiquitination |
| D | 0005515 | molecular_function | protein binding |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0016567 | biological_process | protein ubiquitination |
| D | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| D | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| D | ALA2 | |
| A | CYS196 | |
| A | CYS211 | |
| A | HIS214 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| D | SER33 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| D | SER95 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS1121 | |
| A | SER310 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER314 |
