8R4V
Structure of Salt-inducible kinase 3 in complex with inhibitor
Summary for 8R4V
Entry DOI | 10.2210/pdb8r4v/pdb |
Descriptor | Serine/threonine-protein kinase SIK3, 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]urea (3 entities in total) |
Functional Keywords | kinase, ampk-like, uba, inhibitor complex, drug design, ligase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 115369.60 |
Authors | |
Primary citation | Oster, L.,Castaldo, M.,de Vries, E.,Edfeldt, F.,Pemberton, N.,Gordon, E.,Cederblad, L.,Kack, H. The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity. J.Biol.Chem., 300:107201-107201, 2024 Cited by PubMed: 38508313DOI: 10.1016/j.jbc.2024.107201 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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