8QYA

J22.9-FNY, fully humanized, CDR optimized Fab Fragment based on chimeric J22.9-xi IgG against BCMA; with VH CDR2 glycosylation

Summary for 8QYA

• Entry DOI: 10.2210/pdb8qya/pdb
• Related: 4zfo 8QY9 8QYB
• Descriptor: J22.9-FNY Fab antibody light chain, J22.9-FNY Fab antibody heavy chain, Tumor necrosis factor receptor superfamily member 17, ... (6 entities in total)
• Functional Keywords: fab fragment, humanized, cdr derivatized, bcma binding, immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 3
• Total formula weight: 51035.26

Authors

Marino, S.F.,Daumke, O. (deposition date: 2023-10-25, release date: 2024-01-17, Last modification date: 2024-09-11)

• Primary citation: Marino, S.F.,Daumke, O.; Structure-based humanization of a therapeutic antibody for multiple myeloma.; J.Mol.Med., 102:1151-1161, 2024; PubMed: 39052065; DOI: 10.1007/s00109-024-02470-4

Experimental method

X-RAY DIFFRACTION (2.72 Å)