8QTK
Crystal structure of CBL-b in complex with an allosteric inhibitor (compound 31)
Summary for 8QTK
Entry DOI | 10.2210/pdb8qtk/pdb |
Descriptor | E3 ubiquitin-protein ligase CBL-B, ZINC ION, SODIUM ION, ... (5 entities in total) |
Functional Keywords | e3 ubiquitin ligase, allosteric inhibitor, ligase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 46459.85 |
Authors | Schimpl, M. (deposition date: 2023-10-12, release date: 2024-01-24, Last modification date: 2024-02-07) |
Primary citation | Mfuh, A.M.,Boerth, J.A.,Bommakanti, G.,Chan, C.,Chinn, A.J.,Code, E.,Fricke, P.J.,Giblin, K.A.,Gohlke, A.,Hansel, C.,Hariparsad, N.,Hughes, S.J.,Jin, M.,Kantae, V.,Kavanagh, S.L.,Lamb, M.L.,Lane, J.,Moore, R.,Puri, T.,Quinn, T.R.,Reddy, I.,Robb, G.R.,Robbins, K.J.,Gancedo Rodrigo, M.,Schimpl, M.,Singh, B.,Singh, M.,Tang, H.,Thomson, C.,Walsh, J.J.,Ware, J.,Watson, I.D.G.,Ye, M.W.,Wrigley, G.L.,Zhang, A.X.,Zhang, Y.,Grimster, N.P. Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors. J.Med.Chem., 67:1500-1512, 2024 Cited by PubMed: 38227216DOI: 10.1021/acs.jmedchem.3c02083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.873 Å) |
Structure validation
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