8PQN
NQO1 bound to RBS-10
Summary for 8PQN
Entry DOI | 10.2210/pdb8pqn/pdb |
Descriptor | NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, ~{N}-[4-[(3-methylphenyl)carbonylamino]phenyl]-5-nitro-furan-2-carboxamide (3 entities in total) |
Functional Keywords | nqo1, rbs-10, quinone reductase, degrader resistance, prodrug, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 125407.43 |
Authors | Pous, J.,Jose-Duran, F.,Mayor-Ruiz, C.,Riera, A. (deposition date: 2023-07-11, release date: 2024-01-10, Last modification date: 2024-03-20) |
Primary citation | Barbosa, B.M.G.,Sfyaki, A.,Rafael, S.,Jose-Duran, F.,Pous, J.,Sanchez-Zarzalejo, C.,Perez-Lopez, C.,Vilanova, M.,Cigler, M.,Gay, M.,Vilaseca, M.,Winter, G.E.,Riera, A.,Mayor-Ruiz, C. Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders. Angew.Chem.Int.Ed.Engl., 63:e202316730-e202316730, 2024 Cited by PubMed: 38153885DOI: 10.1002/anie.202316730 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.8 Å) |
Structure validation
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