8PFL
Crystal structure of WRN helicase domain in complex with 3
Summary for 8PFL
Entry DOI | 10.2210/pdb8pfl/pdb |
Descriptor | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION, 2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-7-oxidanylidene-6-[4-(3-oxidanylpyridin-2-yl)carbonylpiperazin-1-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]-~{N}-[2-methyl-4-(trifluoromethyl)phenyl]ethanamide, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 49358.08 |
Authors | Scheufler, C.,Meyer, M.,Moebitz, H. (deposition date: 2023-06-16, release date: 2024-04-24, Last modification date: 2024-05-22) |
Primary citation | Ferretti, S.,Hamon, J.,de Kanter, R.,Scheufler, C.,Andraos-Rey, R.,Barbe, S.,Bechter, E.,Blank, J.,Bordas, V.,Dammassa, E.,Decker, A.,Di Nanni, N.,Dourdoigne, M.,Gavioli, E.,Hattenberger, M.,Heuser, A.,Hemmerlin, C.,Hinrichs, J.,Kerr, G.,Laborde, L.,Jaco, I.,Nunez, E.J.,Martus, H.J.,Quadt, C.,Reschke, M.,Romanet, V.,Schaeffer, F.,Schoepfer, J.,Schrapp, M.,Strang, R.,Voshol, H.,Wartmann, M.,Welly, S.,Zecri, F.,Hofmann, F.,Mobitz, H.,Cortes-Cros, M. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. Nature, 629:443-449, 2024 Cited by PubMed: 38658754DOI: 10.1038/s41586-024-07350-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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