8PFL
Crystal structure of WRN helicase domain in complex with 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | polymer | 431 | 48626.0 | 1 | UniProt (Q14191) Pfam (PF00270) Pfam (PF00271) Pfam (PF16124) | Homo sapiens (human) | DNA helicase,RecQ-like type 3,RecQ protein-like 2,Werner syndrome protein |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-7-oxidanylidene-6-[4-(3-oxidanylpyridin-2-yl)carbonylpiperazin-1-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]-~{N}-[2-methyl-4-(trifluoromethyl)phenyl]ethanamide | non-polymer | 666.6 | 1 | Chemie (YH8) | |||
| 4 | D (A) | water | water | 18.0 | 350 | Chemie (HOH) |
Sequence modifications
A: 517 - 945 (UniProt: Q14191)
| PDB | External Database | Details |
|---|---|---|
| Gly 515 | - | expression tag |
| Pro 516 | - | expression tag |
| Ala 564 | Arg 564 | engineered mutation |
| Ala 625 | Glu 625 | engineered mutation |
| Ala 785 | Arg 785 | engineered mutation |
| Ala 803 | Arg 803 | engineered mutation |
| Ala 886 | Glu 886 | engineered mutation |
| Ala 942 | Arg 942 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48626.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 732.1 | |
| All* | Total formula weight | 49358.1 |
