8PDF
FKBP12 in complex with PROTAC 6a2
Summary for 8PDF
Entry DOI | 10.2210/pdb8pdf/pdb |
Descriptor | Peptidyl-prolyl cis-trans isomerase FKBP1A, (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[4-[(1~{S})-1-[(1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-ethenyl-2-oxidanylidene-3,10-diazabicyclo[4.3.1]decan-3-yl]ethyl]-1,2,3-triazol-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide (3 entities in total) |
Functional Keywords | fkbp12, complex, protac, isomerase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 12875.58 |
Authors | Meyners, C.,Walz, M.,Geiger, T.M.,Hausch, F. (deposition date: 2023-06-12, release date: 2023-11-15, Last modification date: 2024-01-24) |
Primary citation | Geiger, T.M.,Walz, M.,Meyners, C.,Kuehn, A.,Dreizler, J.K.,Sugiarto, W.O.,Maciel, E.V.S.,Zheng, M.,Lermyte, F.,Hausch, F. Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51). Angew.Chem.Int.Ed.Engl., 63:e202309706-e202309706, 2024 Cited by PubMed: 37942685DOI: 10.1002/anie.202309706 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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