8OJH
Crystal structure of human CRBN-DDB1 in complex with compound 4
Summary for 8OJH
Entry DOI | 10.2210/pdb8ojh/pdb |
Descriptor | DNA damage-binding protein 1, Protein cereblon, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | e3-ligase, degradation, glue, protac, protein binding |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 175811.61 |
Authors | Cabry, M.P.,Le Bihan, Y.-V.,van Montfort, R.L.M. (deposition date: 2023-03-24, release date: 2023-07-19, Last modification date: 2023-12-13) |
Primary citation | Bouguenina, H.,Scarpino, A.,O'Hanlon, J.A.,Warne, J.,Wang, H.Z.,Wah Hak, L.C.,Sadok, A.,McAndrew, P.C.,Stubbs, M.,Pierrat, O.A.,Hahner, T.,Cabry, M.P.,Le Bihan, Y.V.,Mitsopoulos, C.,Sialana, F.J.,Roumeliotis, T.I.,Burke, R.,van Montfort, R.L.M.,Choudhari, J.,Chopra, R.,Caldwell, J.J.,Collins, I. A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity. Chembiochem, 24:e202300351-e202300351, 2023 Cited by PubMed: 37418539DOI: 10.1002/cbic.202300351 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.72 Å) |
Structure validation
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