8KHU
Hepatitis B virus core protein Y132A mutant in complex with THPP derivatives 48
Summary for 8KHU
Entry DOI | 10.2210/pdb8khu/pdb |
Descriptor | Capsid protein, ISOPROPYL ALCOHOL, (6~{S},7~{R})-6,7-dimethyl-3-(2-oxidanylidenepyrrolidin-1-yl)-~{N}-[3,4,5-tris(fluoranyl)phenyl]-6,7-dihydro-4~{H}-pyrazolo[1,5-a]pyrazine-5-carboxamide, ... (5 entities in total) |
Functional Keywords | hbv capsid assembly mudulator, antiviral protein, viral protein |
Biological source | Hepatitis B virus adw/991 |
Total number of polymer chains | 7 |
Total formula weight | 125365.51 |
Authors | |
Primary citation | Kou, B.,Zhang, Z.,Han, X.,Zhou, Z.,Xu, Z.,Zhou, X.,Shen, F.,Zhou, Y.,Tian, X.,Yang, G.,Young, J.A.T.,Qiu, H.,Ottaviani, G.,Mayweg, A.,Zhu, W.,Shen, H.C.,Liu, H.,Hu, T. Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus. J.Med.Chem., 66:14116-14132, 2023 Cited by PubMed: 37801325DOI: 10.1021/acs.jmedchem.3c01145 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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