8JYJ
Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid A
Summary for 8JYJ
Entry DOI | 10.2210/pdb8jyj/pdb |
Descriptor | Pol protein,Pol protein,HIV-1 Reverse Transcriptase RNase H active domain, MANGANESE (II) ION, 7-[5-(2-acetamidoethyl)-2-oxidanyl-phenyl]-3,5,6,8-tetrakis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-1,2-dicarboxylic acid, ... (5 entities in total) |
Functional Keywords | inhibitor, viral protein |
Biological source | HIV-1 06TG.HT008 More |
Total number of polymer chains | 1 |
Total formula weight | 17610.41 |
Authors | Ito, Y.,Lu, H.,Kitajima, M.,Ishikawa, H.,Nakata, Y.,Iwatani, Y.,Hoshino, T. (deposition date: 2023-07-03, release date: 2023-08-16, Last modification date: 2024-02-28) |
Primary citation | Ito, Y.,Lu, H.,Kitajima, M.,Ishikawa, H.,Nakata, Y.,Iwatani, Y.,Hoshino, T. Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod., 86:2487-2495, 2023 Cited by PubMed: 37874155DOI: 10.1021/acs.jnatprod.3c00662 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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