8JJ1

Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in two fab conformation

Summary for 8JJ1

Entry DOI	10.2210/pdb8jj1/pdb
EMDB information	36337
Descriptor	Fab 2G7 Heavy Chain, Glutamate receptor ionotropic, NMDA 2A, Glutamate receptor ionotropic, NMDA 1, ... (6 entities in total)
Functional Keywords	nmdar, autoimmune encephalitis, membrane protein
Biological source	Homo sapiens More
Total number of polymer chains	8
Total formula weight	486917.96
Authors	Wang, H.,Zhu, S. (deposition date: 2023-05-29, release date: 2024-06-05, Last modification date: 2024-09-11)
Primary citation	Wang, H.,Xie, C.,Deng, B.,Ding, J.,Li, N.,Kou, Z.,Jin, M.,He, J.,Wang, Q.,Wen, H.,Zhang, J.,Zhou, Q.,Chen, S.,Chen, X.,Yuan, T.F.,Zhu, S. Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 39227720 DOI: 10.1038/s41594-024-01387-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.77 Å)

Structure validation