8JJ1
Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in two fab conformation
Functional Information from PROSITE/UniProt
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
Chain | Residue | Details |
H | TYR202-HIS208 | |
F | TYR190-HIS196 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1408 |
Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P35439 |
Chain | Residue | Details |
B | ARG19-GLN559 | |
B | THR648-ASN812 | |
D | ARG19-GLN559 | |
D | THR648-ASN812 |
site_id | SWS_FT_FI2 |
Number of Residues | 112 |
Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:P35439 |
Chain | Residue | Details |
B | SER560-LEU580 | |
B | ILE631-TYR647 | |
B | MET813-ILE833 | |
D | SER560-LEU580 | |
D | ILE631-TYR647 | |
D | MET813-ILE833 |
site_id | SWS_FT_FI3 |
Number of Residues | 52 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P35439 |
Chain | Residue | Details |
B | ASP581-THR602 | |
B | ARG625-ARG630 | |
D | ASP581-THR602 | |
D | ARG625-ARG630 |
site_id | SWS_FT_FI4 |
Number of Residues | 42 |
Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:A0A1L8F5J9 |
Chain | Residue | Details |
B | LEU603-PRO624 | |
D | LEU603-PRO624 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA |
Chain | Residue | Details |
B | PRO516 | |
C | ASP282 | |
C | SER689 | |
C | TYR730 | |
B | ARG523 | |
B | SER688 | |
B | ASP732 | |
D | PRO516 | |
D | ARG523 | |
D | SER688 | |
D | ASP732 | |
C | GLU266 |
site_id | SWS_FT_FI6 |
Number of Residues | 24 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
B | ASN61 | |
B | ASN491 | |
B | ASN674 | |
B | ASN771 | |
D | ASN61 | |
D | ASN203 | |
D | ASN239 | |
D | ASN276 | |
D | ASN300 | |
D | ASN350 | |
D | ASN368 | |
B | ASN203 | |
D | ASN440 | |
D | ASN471 | |
D | ASN491 | |
D | ASN674 | |
D | ASN771 | |
B | ASN239 | |
B | ASN276 | |
B | ASN300 | |
B | ASN350 | |
B | ASN368 | |
B | ASN440 | |
B | ASN471 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
Chain | Residue | Details |
A | ASN614 | |
C | ASN614 |
site_id | SWS_FT_FI8 |
Number of Residues | 14 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN75 | |
C | ASN380 | |
C | ASN443 | |
C | ASN444 | |
C | ASN541 | |
C | ASN687 | |
A | ASN340 | |
A | ASN380 | |
A | ASN443 | |
A | ASN444 | |
A | ASN541 | |
A | ASN687 | |
C | ASN75 | |
C | ASN340 |