8JF5
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAS1440
Summary for 8JF5
Entry DOI | 10.2210/pdb8jf5/pdb |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total) |
Functional Keywords | histone demethylase, flavoprotein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 90660.24 |
Authors | Fukushima, H.,Machida, T.,Yamashita, S.,Suzuki, T. (deposition date: 2023-05-17, release date: 2024-05-22) |
Primary citation | Machida, T.,Tsukioka, S.,Gong, Y.,Onodera, A.,Nakayama, A.,Hashimoto, N.,Ohkubo, S.,Tanaka, T. TAS1440, a histone H3 competitive LSD1 inhibitor, activates both TGF-beta and notch signaling pathways via INSM1 dissociation in neuroendocrine small cell lung cancer To Be Published, |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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