8IBQ
Bromodomain and Extra-terminal Domain (BET) BRD4
Summary for 8IBQ
Entry DOI | 10.2210/pdb8ibq/pdb |
Descriptor | Bromodomain-containing protein 4, 7-[2-fluoranyl-3-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1~{H}-imidazo[4,5-b]pyridine (3 entities in total) |
Functional Keywords | binds acetylated lysine residues, dna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 14974.32 |
Authors | |
Primary citation | Chen, X.,Cao, D.,Liu, C.,Meng, F.,Zhang, Z.,Xu, R.,Tong, Y.,Xin, Y.,Zhang, W.,Kang, W.,Bao, Q.,Shen, J.,Xiong, B.,You, Q.,Jiang, Z. Discovery of 1 H -Imidazo[4,5- b ]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain. J.Med.Chem., 66:8725-8744, 2023 Cited by PubMed: 37382379DOI: 10.1021/acs.jmedchem.3c00372 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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