8HF8
Human PPAR delta ligand binding domain in complex with a synthetic agonist V1
Summary for 8HF8
Entry DOI | 10.2210/pdb8hf8/pdb |
Descriptor | Peroxisome proliferator-activated receptor delta, 2-[4-[[2,5-bis(oxidanylidene)-3-[4-(trifluoromethyl)phenyl]imidazolidin-1-yl]methyl]-2,6-dimethyl-phenoxy]-2-methyl-propanoic acid, octyl beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | complex, agonist, peroxisome proliferator-activated receptor, nuclear protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 66234.81 |
Authors | |
Primary citation | Feng, Z.,Xiang, J.,Sun, G.,Liu, H.,Wang, Y.,Liu, X.,Feng, J.,Xu, Q.,Wen, X.,Yuan, H.,Sun, H.,Dai, L. Discovery of the First Subnanomolar PPAR alpha / delta Dual Agonist for the Treatment of Cholestatic Liver Diseases. J.Med.Chem., 66:7331-7354, 2023 Cited by PubMed: 37243609DOI: 10.1021/acs.jmedchem.2c02123 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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