8H7B
The crystal structure of human mcl1 kinase domain in complex with MCL1-M-EBA
Summary for 8H7B
Entry DOI | 10.2210/pdb8h7b/pdb |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, 7-[3-(isoquinolin-7-yloxymethyl)-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1H-indole-2-carboxylic acid (3 entities in total) |
Functional Keywords | complex, inhibitor, lysine, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 36011.04 |
Authors | Zhu, C.J.,Zhang, Z.M. (deposition date: 2022-10-19, release date: 2023-02-22, Last modification date: 2024-02-07) |
Primary citation | Chen, P.,Tang, G.,Zhu, C.,Sun, J.,Wang, X.,Xiang, M.,Huang, H.,Wang, W.,Li, L.,Zhang, Z.M.,Gao, L.,Yao, S.Q. 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J.Am.Chem.Soc., 2023 Cited by PubMed: 36774655DOI: 10.1021/jacs.2c11595 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4640844632 Å) |
Structure validation
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