8GHR
Structure of human ENPP1 in complex with variable heavy domain VH27.2
Summary for 8GHR
Entry DOI | 10.2210/pdb8ghr/pdb |
EMDB information | 40047 |
Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form, Immunoglobulin gamma-1 heavy chain fusion, VH27, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | phosphodiesterase, inhibitor, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 261723.97 |
Authors | Carozza, J.A.,Wang, H.,Solomon, P.E.,Wells, J.A.,Li, L. (deposition date: 2023-03-10, release date: 2023-08-02, Last modification date: 2024-01-03) |
Primary citation | Solomon, P.E.,Bracken, C.J.,Carozza, J.A.,Wang, H.,Young, E.P.,Wellner, A.,Liu, C.C.,Sweet-Cordero, E.A.,Li, L.,Wells, J.A. Discovery of VH domains that allosterically inhibit ENPP1. Nat.Chem.Biol., 20:30-41, 2024 Cited by PubMed: 37400538DOI: 10.1038/s41589-023-01368-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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