8GHR
Structure of human ENPP1 in complex with variable heavy domain VH27.2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form, Immunoglobulin gamma-1 heavy chain fusion | polymer | 1015 | 115488.6 | 2 | UniProt (P22413) UniProt (P0DOX5) Pfam (PF01663) Pfam (PF01223) | Homo sapiens (human) | Immunoglobulin gamma-1 heavy chain NIE |
| 2 | C, D (C, D) | VH27 | polymer | 124 | 13564.0 | 2 | Homo sapiens (human) | ||
| 3 | E, F, G, H (E, F, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 4 | I, J, O, P (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | K, Q (A, B) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 6 | L, M, R, S (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 7 | N, T (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) PubChem (271) | |||
| 8 | U, V (A, B) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: 186 - 925 (UniProt: P22413)
A, B: 948 - 1179 (UniProt: P0DOX5)
| PDB | External Database | Details |
|---|---|---|
| Ala 256 | Thr 256 | conflict |
| Thr 926 | - | linker |
| Ser 927 | - | linker |
| Ser 928 | - | linker |
| Gly 929 | - | linker |
| Gly 930 | - | linker |
| Gly 931 | - | linker |
| Gly 932 | - | linker |
| Glu 933 | - | linker |
| Asn 934 | - | linker |
| Leu 935 | - | linker |
| Tyr 936 | - | linker |
| Phe 937 | - | linker |
| Gln 938 | - | linker |
| Ser 939 | - | linker |
| Ser 940 | - | linker |
| Gly 941 | - | linker |
| Gly 942 | - | linker |
| Gly 943 | - | linker |
| Ser 944 | - | linker |
| Gly 945 | - | linker |
| Gly 946 | - | linker |
| Gly 947 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 1180 | - | expression tag |
| Gly 1181 | - | expression tag |
| Gly 1182 | - | expression tag |
| Gly 1183 | - | expression tag |
| Ser 1184 | - | expression tag |
| Gly 1185 | - | expression tag |
| Leu 1186 | - | expression tag |
| Asn 1187 | - | expression tag |
| Asp 1188 | - | expression tag |
| Ile 1189 | - | expression tag |
| Phe 1190 | - | expression tag |
| Glu 1191 | - | expression tag |
| Ala 1192 | - | expression tag |
| Gln 1193 | - | expression tag |
| Lys 1194 | - | expression tag |
| Ile 1195 | - | expression tag |
| Glu 1196 | - | expression tag |
| Trp 1197 | - | expression tag |
| His 1198 | - | expression tag |
| Glu 1199 | - | expression tag |
| Gly 1200 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 258105.3 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1921.1 | |
| All* | Total formula weight | 261724.0 |
