8GHR
Structure of human ENPP1 in complex with variable heavy domain VH27.2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form, Immunoglobulin gamma-1 heavy chain fusion | polymer | 1015 | 115488.6 | 2 | UniProt (P22413) UniProt (P0DOX5) Pfam (PF01663) Pfam (PF01223) Pfam (PF07654) | Homo sapiens (human) | Immunoglobulin gamma-1 heavy chain NIE |
| 2 | C, D (C, D) | VH27 | polymer | 124 | 13564.0 | 2 | Homo sapiens (human) | ||
| 3 | E, F, G, H (E, F, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 4 | I, J, O, P (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | K, Q (A, B) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) | |||
| 6 | L, M, R, S (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 7 | N, T (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 8 | U, V (A, B) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: 186 - 925 (UniProt: P22413)
A, B: 948 - 1179 (UniProt: P0DOX5)
| PDB | External Database | Details |
|---|---|---|
| Ala 256 | Thr 256 | conflict |
| Thr 926 | - | linker |
| Ser 927 | - | linker |
| Ser 928 | - | linker |
| Gly 929 | - | linker |
| Gly 930 | - | linker |
| Gly 931 | - | linker |
| Gly 932 | - | linker |
| Glu 933 | - | linker |
| Asn 934 | - | linker |
| Leu 935 | - | linker |
| Tyr 936 | - | linker |
| Phe 937 | - | linker |
| Gln 938 | - | linker |
| Ser 939 | - | linker |
| Ser 940 | - | linker |
| Gly 941 | - | linker |
| Gly 942 | - | linker |
| Gly 943 | - | linker |
| Ser 944 | - | linker |
| Gly 945 | - | linker |
| Gly 946 | - | linker |
| Gly 947 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 1180 | - | expression tag |
| Gly 1181 | - | expression tag |
| Gly 1182 | - | expression tag |
| Gly 1183 | - | expression tag |
| Ser 1184 | - | expression tag |
| Gly 1185 | - | expression tag |
| Leu 1186 | - | expression tag |
| Asn 1187 | - | expression tag |
| Asp 1188 | - | expression tag |
| Ile 1189 | - | expression tag |
| Phe 1190 | - | expression tag |
| Glu 1191 | - | expression tag |
| Ala 1192 | - | expression tag |
| Gln 1193 | - | expression tag |
| Lys 1194 | - | expression tag |
| Ile 1195 | - | expression tag |
| Glu 1196 | - | expression tag |
| Trp 1197 | - | expression tag |
| His 1198 | - | expression tag |
| Glu 1199 | - | expression tag |
| Gly 1200 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 258105.3 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1921.1 | |
| All* | Total formula weight | 261724.0 |
