8GHR

Structure of human ENPP1 in complex with variable heavy domain VH27.2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0003676	molecular_function	nucleic acid binding
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FSCSVMH

Chain	Residue	Details
A	PHE1155-HIS1161

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: AMP-threonine intermediate => ECO:0000250|UniProtKB:P06802

Chain	Residue	Details
A	ALA256
B	ALA256

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site_id	SWS_FT_FI2
Number of Residues	34
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P06802

Chain	Residue	Details
A	ASP218
A	HIS424
A	SER532
A	HIS535
A	ASP800
A	ASP802
A	ASP804
A	ARG806
A	ASP808
B	ASP218
B	ALA256
A	ALA256
B	ASN277
B	LEU290
B	LYS295
B	TYR340
B	ASP376
B	HIS380
B	ASP423
B	HIS424
B	SER532
B	HIS535
A	ASN277
B	ASP800
B	ASP802
B	ASP804
B	ARG806
B	ASP808
A	LEU290
A	LYS295
A	TYR340
A	ASP376
A	HIS380
A	ASP423

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Essential for catalytic activity => ECO:0000250|UniProtKB:Q9R1E6

Chain	Residue	Details
A	LYS915
B	LYS915

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q924C3

Chain	Residue	Details
A	ALA256
B	ALA256

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site_id	SWS_FT_FI5
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN285
B	ASN731
A	ASN477
A	ASN585
A	ASN700
A	ASN731
B	ASN285
B	ASN477
B	ASN585
B	ASN700

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN341
B	ASN341

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site_id	SWS_FT_FI7
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN643
A	ASN748
B	ASN643
B	ASN748

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site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19358553

Chain	Residue	Details
A	ASN1029
B	ASN1029

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