8GEQ

E. eligens beta-glucuronidase bound to ceritinib-glucuronide

Summary for 8GEQ

Entry DOI	10.2210/pdb8geq/pdb
Descriptor	Beta-glucuronidase, 4-amino-5-chloro-2-{4-(1-beta-D-glucopyranuronosylpiperidin-4-yl)-5-methyl-2-[(propan-2-yl)oxy]anilino}pyrimidine (3 entities in total)
Functional Keywords	beta-glucuronidase, inhibitor, glucuronide, hydrolase
Biological source	Lachnospira eligens
Total number of polymer chains	1
Total formula weight	70387.14
Authors	Simpson, J.B.,Kowalewski, M.K.,Redinbo, M.R. (deposition date: 2023-03-07, release date: 2024-02-14, Last modification date: 2024-09-04)
Primary citation	Simpson, J.B.,Walker, M.E.,Sekela, J.J.,Ivey, S.M.,Jariwala, P.B.,Storch, C.M.,Kowalewski, M.E.,Graboski, A.L.,Lietzan, A.D.,Walton, W.G.,Davis, K.A.,Cloer, E.W.,Borlandelli, V.,Hsiao, Y.C.,Roberts, L.R.,Perlman, D.H.,Liang, X.,Overkleeft, H.S.,Bhatt, A.P.,Lu, K.,Redinbo, M.R. Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32:925-944.e10, 2024 Cited by PubMed: 38754417 DOI: 10.1016/j.chom.2024.04.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation