8G8W

Molecular mechanism of nucleotide inhibition of human uncoupling protein 1

Summary for 8G8W

Entry DOI	10.2210/pdb8g8w/pdb
EMDB information	29857
Descriptor	Mitochondrial brown fat uncoupling protein 1, Pro-macrobody 71, Maltose/maltodextrin-binding periplasmic protein chimera, Pro-Macrobody 65, Maltose/maltodextrin-binding periplasmic protein chimera, ... (6 entities in total)
Functional Keywords	slc25, mitochondrial carrier, uncoupling, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	146103.96
Authors	Gogoi, P.,Jones, S.A.,Ruprecht, J.J.,King, M.S.,Lee, Y.,Zogg, T.,Pardon, E.,Chand, D.,Steimle, S.,Copeman, D.,Cotrim, C.A.,Steyaert, J.,Crichton, P.G.,Moiseenkova-Bell, V.,Kunji, E.R.S. (deposition date: 2023-02-20, release date: 2023-06-07)
Primary citation	Jones, S.A.,Gogoi, P.,Ruprecht, J.J.,King, M.S.,Lee, Y.,Zogg, T.,Pardon, E.,Chand, D.,Steimle, S.,Copeman, D.M.,Cotrim, C.A.,Steyaert, J.,Crichton, P.G.,Moiseenkova-Bell, V.,Kunji, E.R.S. Structural basis of purine nucleotide inhibition of human uncoupling protein 1. Sci Adv, 9:eadh4251-eadh4251, 2023 Cited by PubMed: 37256948 DOI: 10.1126/sciadv.adh4251 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation