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8G8W

Molecular mechanism of nucleotide inhibition of human uncoupling protein 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0002024biological_processdiet induced thermogenesis
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005739cellular_componentmitochondrion
A0005740cellular_componentmitochondrial envelope
A0005743cellular_componentmitochondrial inner membrane
A0006357biological_processregulation of transcription by RNA polymerase II
A0006839biological_processmitochondrial transport
A0009266biological_processresponse to temperature stimulus
A0009409biological_processresponse to cold
A0015078molecular_functionproton transmembrane transporter activity
A0017077molecular_functionoxidative phosphorylation uncoupler activity
A0019003molecular_functionGDP binding
A0022857molecular_functiontransmembrane transporter activity
A0031667biological_processresponse to nutrient levels
A0032555molecular_functionpurine ribonucleotide binding
A0032870biological_processcellular response to hormone stimulus
A0034220biological_processmonoatomic ion transmembrane transport
A0034614biological_processcellular response to reactive oxygen species
A0036041molecular_functionlong-chain fatty acid binding
A0050873biological_processbrown fat cell differentiation
A0055085biological_processtransmembrane transport
A0070417biological_processcellular response to cold
A0071398biological_processcellular response to fatty acid
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1901612molecular_functioncardiolipin binding
A1902600biological_processproton transmembrane transport
A1903426biological_processregulation of reactive oxygen species biosynthetic process
A1903495biological_processcellular response to dehydroepiandrosterone
A1990542biological_processmitochondrial transmembrane transport
A1990845biological_processadaptive thermogenesis
B0005515molecular_functionprotein binding
B0006974biological_processDNA damage response
B0008643biological_processcarbohydrate transport
B0015144molecular_functioncarbohydrate transmembrane transporter activity
B0015768biological_processmaltose transport
B0016020cellular_componentmembrane
B0030288cellular_componentouter membrane-bounded periplasmic space
B0034219biological_processcarbohydrate transmembrane transport
B0034289biological_processdetection of maltose stimulus
B0042597cellular_componentperiplasmic space
B0042956biological_processmaltodextrin transmembrane transport
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B0055085biological_processtransmembrane transport
B0060326biological_processcell chemotaxis
B1901982molecular_functionmaltose binding
B1990060cellular_componentmaltose transport complex
C0005515molecular_functionprotein binding
C0006974biological_processDNA damage response
C0008643biological_processcarbohydrate transport
C0015144molecular_functioncarbohydrate transmembrane transporter activity
C0015768biological_processmaltose transport
C0016020cellular_componentmembrane
C0030288cellular_componentouter membrane-bounded periplasmic space
C0034219biological_processcarbohydrate transmembrane transport
C0034289biological_processdetection of maltose stimulus
C0042597cellular_componentperiplasmic space
C0042956biological_processmaltodextrin transmembrane transport
C0043190cellular_componentATP-binding cassette (ABC) transporter complex
C0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C0055085biological_processtransmembrane transport
C0060326biological_processcell chemotaxis
C1901982molecular_functionmaltose binding
C1990060cellular_componentmaltose transport complex
Functional Information from PROSITE/UniProt
site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
BPRO228-ASN245
CPRO232-ASN249

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues21
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
APRO11-PHE32

site_idSWS_FT_FI2
Number of Residues117
DetailsTOPO_DOM: Mitochondrial matrix => ECO:0000250|UniProtKB:P04633
ChainResidueDetails
APRO33-LYS73
ATHR134-THR178
AVAL233-ALA266

site_idSWS_FT_FI3
Number of Residues22
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
ALEU74-TYR96

site_idSWS_FT_FI4
Number of Residues52
DetailsTOPO_DOM: Mitochondrial intermembrane => ECO:0000250|UniProtKB:P04633
ChainResidueDetails
AASP97-LYS116
AASP196-VAL212
AGLU290-THR307

site_idSWS_FT_FI5
Number of Residues16
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
AILE117-PRO133

site_idSWS_FT_FI6
Number of Residues16
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
APRO179-TYR195

site_idSWS_FT_FI7
Number of Residues19
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
APRO213-PRO232

site_idSWS_FT_FI8
Number of Residues22
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
APHE267-PHE289

site_idSWS_FT_FI9
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:28781081
ChainResidueDetails
ALYS56
ALYS269

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Cysteine sulfenic acid (-SOH) => ECO:0000250|UniProtKB:P12242
ChainResidueDetails
ACYS254

226262

PDB entries from 2024-10-16

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