8G4O

Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with didesethylflurazepam and endogenous GABA

Summary for 8G4O

Entry DOI	10.2210/pdb8g4o/pdb
EMDB information	29728
Descriptor	Gamma-aminobutyric acid receptor subunit alpha-1, (5M)-1-(2-aminoethyl)-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	ligand-gated ion channel, cys-loop receptor, neurotransmitter receptor, membrane protein
Biological source	Mus musculus More
Total number of polymer chains	9
Total formula weight	380030.87
Authors	Sun, C.,Gouaux, E. (deposition date: 2023-02-10, release date: 2023-09-20, Last modification date: 2023-11-15)
Primary citation	Sun, C.,Zhu, H.,Clark, S.,Gouaux, E. Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622:195-201, 2023 Cited by PubMed: 37730991 DOI: 10.1038/s41586-023-06556-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.06 Å)

Structure validation