8G4O

Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with didesethylflurazepam and endogenous GABA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0004890	molecular_function	GABA-A receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0007214	biological_process	gamma-aminobutyric acid signaling pathway
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0004890	molecular_function	GABA-A receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0004890	molecular_function	GABA-A receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006821	biological_process	chloride transport
C	0007214	biological_process	gamma-aminobutyric acid signaling pathway
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0004890	molecular_function	GABA-A receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006821	biological_process	chloride transport
D	0007214	biological_process	gamma-aminobutyric acid signaling pathway
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0004890	molecular_function	GABA-A receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CqLqLhnFPmDehsC

Chain	Residue	Details
D	CYS151-CYS165
B	CYS136-CYS150
A	CYS138-CYS152

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
K	TYR191-HIS197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	247
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
D	GLN1-PHE236
D	ARG284-ALA295
D	TYR435-LEU436
C	GLN1-PHE225
C	ASN274-THR283
C	TYR414-GLN428

---

site_id	SWS_FT_FI2
Number of Residues	84
Details	TRANSMEM: Helical => ECO:0000250|UniProtKB:P18507

Chain	Residue	Details
D	THR237-ILE257
D	ALA264-ALA283
D	MET296-PHE320
D	TYR413-LEU434
E	PHE221-ILE242
E	ALA246-LEU268
E	ALA280-VAL302
E	TRP466-VAL487

---

site_id	SWS_FT_FI3
Number of Residues	96
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
D	ASN258-PRO263
D	VAL321-SER412
C	ASN247-VAL251
C	VAL306-ARG393

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000305

Chain	Residue	Details
D	SER343
B	SER156
B	THR202
E	TYR97
E	SER156
E	THR202

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
D	ASN13
D	ASN90
D	ASN208

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18034455

Chain	Residue	Details
B	TYR417
E	TYR417
C	ASN10
C	ASN110

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN8
B	ASN80
B	ASN149
E	ASN8
E	ASN80
E	ASN149

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