8G1V

Crystal Structure Matriptase (C731S) in Complex with Inhibitor MM1132-2

Summary for 8G1V

• Entry DOI: 10.2210/pdb8g1v/pdb
• Descriptor: Suppressor of tumorigenicity 14 protein, SULFATE ION, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: matriptase, inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 27805.15

Authors

Lovell, S.,Kashipathy, M.M.,Battaile, K.P.,Janetka, J.W. (deposition date: 2023-02-03, release date: 2024-07-10, Last modification date: 2024-08-07)

• Primary citation: Mahoney, M.W.,Helander, J.,Kooner, A.S.,Norman, M.,Damalanka, V.C.,De Bona, P.,Kasperkiewicz, P.,Rut, W.,Poreba, M.,Kashipathy, M.M.,Battaile, K.P.,Lovell, S.,O'Donoghue, A.J.,Craik, C.S.,Drag, M.,Janetka, J.W.; Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin; Protein Sci., 33:-, 2024; DOI: 10.1002/pro.5110

Experimental method

X-RAY DIFFRACTION (1.35 Å)