8FIS
Structure of Bispecific CAP256V2LS-J3 Fab in complex with BG505 DS-SOSIP.664
Summary for 8FIS
Entry DOI | 10.2210/pdb8fis/pdb |
EMDB information | 29209 |
Descriptor | Envelope glycoprotein gp41, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... (10 entities in total) |
Functional Keywords | cd4, hiv-1, sosip, vaccine, immune system, llama, v2 apex, therapeutic, viral protein, cap256, vrc26.25 |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 10 |
Total formula weight | 381232.65 |
Authors | Gorman, J.,Kwong, P.D. (deposition date: 2022-12-16, release date: 2023-02-01, Last modification date: 2023-02-15) |
Primary citation | Zhang, B.,Gorman, J.,Kwon, Y.D.,Pegu, A.,Chao, C.W.,Liu, T.,Asokan, M.,Bender, M.F.,Bylund, T.,Damron, L.,Gollapudi, D.,Lei, P.,Li, Y.,Liu, C.,Louder, M.K.,McKee, K.,Olia, A.S.,Rawi, R.,Schon, A.,Wang, S.,Yang, E.S.,Yang, Y.,Carlton, K.,Doria-Rose, N.A.,Shapiro, L.,Seaman, M.S.,Mascola, J.R.,Kwong, P.D. Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency. Mabs, 15:2165390-2165390, 2023 Cited by PubMed: 36729903DOI: 10.1080/19420862.2023.2165390 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.18 Å) |
Structure validation
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