8FHW
Cryo-EM structure of Cryptococcus neoformans trehalose-6-phosphate synthase homotetramer in complex with uridine diphosphate and glucose-6-phosphate
Summary for 8FHW
Entry DOI | 10.2210/pdb8fhw/pdb |
EMDB information | 29172 |
Descriptor | Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE, 6-O-phosphono-alpha-D-glucopyranose (3 entities in total) |
Functional Keywords | glycosyltransferase, complex, transferase |
Biological source | Cryptococcus neoformans var. grubii H99 |
Total number of polymer chains | 4 |
Total formula weight | 309919.19 |
Authors | Washington, E.J.,Brennan, R.G. (deposition date: 2022-12-15, release date: 2023-12-20, Last modification date: 2024-06-26) |
Primary citation | Washington, E.J.,Zhou, Y.,Hsu, A.L.,Petrovich, M.,Tenor, J.L.,Toffaletti, D.L.,Guan, Z.,Perfect, J.R.,Borgnia, M.J.,Bartesaghi, A.,Brennan, R.G. Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans : a target for novel antifungals. Biorxiv, 2024 Cited by PubMed: 36993618DOI: 10.1101/2023.03.14.530545 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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