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8F59

LSD1-CoREST in complex with AW2 and SNAG peptide

Summary for 8F59
Entry DOI10.2210/pdb8f59/pdb
DescriptorLysine-specific histone demethylase 1A, REST corepressor 1, Zinc finger protein SNAI1, ... (4 entities in total)
Functional Keywordsepigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase
Biological sourceHomo sapiens (human)
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Total number of polymer chains3
Total formula weight113609.55
Authors
Caroli, J.,Mattevi, A. (deposition date: 2022-11-12, release date: 2024-06-12)
Primary citationCaroli, J.,Mattevi, A.
Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1
to be published,
Experimental method
Structure validation

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PDB entries from 2024-08-14

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