8F2B
Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45
Summary for 8F2B
Entry DOI | 10.2210/pdb8f2b/pdb |
EMDB information | 28812 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, PALMITIC ACID, (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, ... (13 entities in total) |
Functional Keywords | gpcr, amylin receptor, dual amylin and calcitonin receptor agonists, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 7 |
Total formula weight | 191394.26 |
Authors | Cao, J.,Sexton, P.M.,Wootten, D.L.,Belousoff, M.J. (deposition date: 2022-11-07, release date: 2023-08-02, Last modification date: 2024-03-13) |
Primary citation | Cao, J.,Belousoff, M.J.,Gerrard, E.,Danev, R.,Fletcher, M.M.,Dal Maso, E.,Schreuder, H.,Lorenz, K.,Evers, A.,Tiwari, G.,Besenius, M.,Li, Z.,Johnson, R.M.,Wootten, D.,Sexton, P.M. Structural insight into selectivity of amylin and calcitonin receptor agonists. Nat.Chem.Biol., 20:162-169, 2024 Cited by PubMed: 37537379DOI: 10.1038/s41589-023-01393-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2 Å) |
Structure validation
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