8F0M
Monobody 12D5 bound to KRAS(G12D)
Summary for 8F0M
Entry DOI | 10.2210/pdb8f0m/pdb |
Related | 8EZG |
Descriptor | Isoform 2B of GTPase KRas, Monobody 12D5, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | signaling protein-de novo protein complex, signaling protein/de novo protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 60917.83 |
Authors | Hattori, T.,Glasser, E.,Akkapeddi, P.,Ketavarapu, G.,Teng, K.W.,Koide, A.,Koide, S. (deposition date: 2022-11-03, release date: 2023-07-19, Last modification date: 2023-10-25) |
Primary citation | Akkapeddi, P.,Hattori, T.,Khan, I.,Glasser, E.,Koide, A.,Ketavarapu, G.,Whaby, M.,Zuberi, M.,Teng, K.W.,Lefler, J.,Maso, L.,Bang, I.,Ostrowski, M.C.,O'Bryan, J.P.,Koide, S. Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors. Proc.Natl.Acad.Sci.USA, 120:e2302485120-e2302485120, 2023 Cited by PubMed: 37399416DOI: 10.1073/pnas.2302485120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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