8EWV
DNA-encoded library (DEL)-enabled discovery of proximity inducing small molecules
Summary for 8EWV
Entry DOI | 10.2210/pdb8ewv/pdb |
Descriptor | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total) |
Functional Keywords | molecular glue, bifunctional compound, brd4, vcb, dna-encoded libraries, apoptosis |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 24 |
Total formula weight | 352458.72 |
Authors | Schreiber, S.L.,Shu, W.,Ma, X.,Michaud, G.,Bonazzi, S.,Berst, F. (deposition date: 2022-10-24, release date: 2023-10-04, Last modification date: 2024-02-14) |
Primary citation | Mason, J.W.,Chow, Y.T.,Hudson, L.,Tutter, A.,Michaud, G.,Westphal, M.V.,Shu, W.,Ma, X.,Tan, Z.Y.,Coley, C.W.,Clemons, P.A.,Bonazzi, S.,Berst, F.,Briner, K.,Liu, S.,Zecri, F.J.,Schreiber, S.L. DNA-encoded library-enabled discovery of proximity-inducing small molecules. Nat.Chem.Biol., 20:170-179, 2024 Cited by PubMed: 37919549DOI: 10.1038/s41589-023-01458-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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