8ET7
Cryo-EM structure of the organic cation transporter 1 in complex with diphenhydramine
Summary for 8ET7
Entry DOI | 10.2210/pdb8et7/pdb |
EMDB information | 28587 |
Descriptor | OCT1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE (3 entities in total) |
Functional Keywords | organic cation, transport, membrane protein, transport protein |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 61979.32 |
Authors | Suo, Y.,Wright, N.J.,Lee, S.-Y. (deposition date: 2022-10-16, release date: 2023-05-31, Last modification date: 2023-08-02) |
Primary citation | Suo, Y.,Wright, N.J.,Guterres, H.,Fedor, J.G.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.Y. Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat.Struct.Mol.Biol., 30:1001-1011, 2023 Cited by PubMed: 37291422DOI: 10.1038/s41594-023-01017-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.77 Å) |
Structure validation
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