8EOO

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibodies WRAIR-2063 and WRAIR-2151

Summary for 8EOO

• Entry DOI: 10.2210/pdb8eoo/pdb
• Descriptor: WRAIR-2151 antibody Fab heavy chain, WRAIR-2151 antibody Fab light chain, Spike protein S1, ... (8 entities in total)
• Functional Keywords: viral protein, immune system, complex, human antibodies
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 10
• Total formula weight: 237870.62

Authors

Jensen, J.L.,Sankhala, R.S.,Joyce, M.G. (deposition date: 2022-10-03, release date: 2023-06-14, Last modification date: 2023-10-25)

• Primary citation: Jensen, J.L.,Sankhala, R.S.,Dussupt, V.,Bai, H.,Hajduczki, A.,Lal, K.G.,Chang, W.C.,Martinez, E.J.,Peterson, C.E.,Golub, E.S.,Rees, P.A.,Mendez-Rivera, L.,Zemil, M.,Kavusak, E.,Mayer, S.V.,Wieczorek, L.,Kannan, S.,Doranz, B.J.,Davidson, E.,Yang, E.S.,Zhang, Y.,Chen, M.,Choe, M.,Wang, L.,Gromowski, G.D.,Koup, R.A.,Michael, N.L.,Polonis, V.R.,Rolland, M.,Modjarrad, K.,Krebs, S.J.,Joyce, M.G.; Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity.; J.Virol., 97:e0159622-e0159622, 2023; PubMed: 37395646; DOI: 10.1128/jvi.01596-22

Experimental method

X-RAY DIFFRACTION (2.77 Å)