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Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibodies WRAIR-2063 and WRAIR-2151

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (A, F)	WRAIR-2151 antibody Fab heavy chain	polymer	223	23743.6	2		Homo sapiens (human)
2	B, I (B, K)	WRAIR-2151 antibody Fab light chain	polymer	216	23209.4	2		Homo sapiens (human)
3	C, D (C, D)	Spike protein S1	polymer	205	23073.8	2	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
4	E, G (E, H)	WRAIR-2063 antibody Fab heavy chain	polymer	227	24313.2	2		Homo sapiens (human)
5	H, J (J, L)	WRAIR-2063 antibody Fab light chain	polymer	219	24097.8	2		Homo sapiens (human)
6	K, L, O, P, Q... (B, D, F, K, L)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
7	M, N (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
8	AA, BA, S, T, U... (K, L, A, B, C...)	water	water		18.0	77	Chemie (HOH)

Sequence modifications

C, D: 331 - 527 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 528	-	expression tag
Ser 529	-	expression tag
His 530	-	expression tag
His 531	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	236875.6
Non-Polymers*	Number of molecules	8
	Total formula weight	995.0
All*	Total formula weight	237870.6

*Water molecules are not included.