8EOG
Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine
Summary for 8EOG
Entry DOI | 10.2210/pdb8eog/pdb |
EMDB information | 28375 28561 28564 |
Descriptor | Voltage-dependent calcium channel subunit alpha-2/delta-1, CHOLESTEROL, (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, ... (13 entities in total) |
Functional Keywords | voltage-gated calcium channel, cav alpha2delta, drug binding, gabapentinoid, membrane protein |
Biological source | Oryctolagus cuniculus (rabbit) More |
Total number of polymer chains | 3 |
Total formula weight | 316630.21 |
Authors | Chen, Z.,Mondal, A.,Abderemane-Ali, F.,Minor, D.L. (deposition date: 2022-10-03, release date: 2023-05-24, Last modification date: 2023-07-26) |
Primary citation | Chen, Z.,Mondal, A.,Abderemane-Ali, F.,Jang, S.,Niranjan, S.,Montano, J.L.,Zaro, B.W.,Minor Jr., D.L. EMC chaperone-Ca V structure reveals an ion channel assembly intermediate. Nature, 619:410-419, 2023 Cited by PubMed: 37196677DOI: 10.1038/s41586-023-06175-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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