8DVM
Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.6
Summary for 8DVM
Entry DOI | 10.2210/pdb8dvm/pdb |
Descriptor | Low-density lipoprotein receptor-related protein 6, E3.6 Disulfide constrained peptide, alpha-L-fucopyranose-(1-3)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | lrp6, e3e4, wnt signaling, signaling protein, disulfide constrained peptide, wnt agonism |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 79297.82 |
Authors | Thakur, A.K.,Liau, N.P.D.,Sudhamsu, J.,Hannoush, R.N. (deposition date: 2022-07-29, release date: 2023-03-29, Last modification date: 2023-11-15) |
Primary citation | Thakur, A.K.,Miller, S.E.,Liau, N.P.D.,Hwang, S.,Hansen, S.,de Sousa E Melo, F.,Sudhamsu, J.,Hannoush, R.N. Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering. Acs Chem.Biol., 18:772-784, 2023 Cited by PubMed: 36893429DOI: 10.1021/acschembio.2c00753 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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