8DKS
IRAK4 IN COMPLEX WITH COMPOUND #3
Summary for 8DKS
Entry DOI | 10.2210/pdb8dks/pdb |
Descriptor | Interleukin-1 receptor-associated kinase 4, (1S,2S,3R,4R)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide, BETA-MERCAPTOETHANOL, ... (4 entities in total) |
Functional Keywords | kinase inhibitor, irak4, pyrimidine, atp binding, protein binding, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 104444.48 |
Authors | |
Primary citation | Chen, Y.,Tso, K.,Heckrodt, T.J.,Li, H.,Yen, R.,Lin, N.,Singh, R.,Taylor, V.,Masuda, E.S.,Park, G.,Payan, D.G. Bicyclic pyrimidine compounds as potent IRAK4 inhibitors. Bioorg.Med.Chem.Lett., 73:128900-128900, 2022 Cited by PubMed: 35863718DOI: 10.1016/j.bmcl.2022.128900 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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