8DC4
Crystal structure of p53 Y220C covalently bound to carbazole KG3
Summary for 8DC4
Entry DOI | 10.2210/pdb8dc4/pdb |
Descriptor | Cellular tumor antigen p53, ZINC ION, 9-propanoyl-9H-carbazole-3-carbaldehyde, bound form, ... (4 entities in total) |
Functional Keywords | tp53, tumor suppressor, cell cycle |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 100770.82 |
Authors | Guiley, K.Z.,Shokat, K.M. (deposition date: 2022-06-15, release date: 2022-10-12, Last modification date: 2023-10-25) |
Primary citation | Guiley, K.Z.,Shokat, K.M. A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability. Cancer Discov, 13:56-69, 2023 Cited by PubMed: 36197521DOI: 10.1158/2159-8290.CD-22-0381 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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